Summary of the Medical History of S.D.

S.D., born 22 September 1992. Suspected diagnosis at birth – lymph hemangioma of the left wall or the thorax and abdomen.

11 November 1992, Universitäts-Kinderklinik Vienna: partial resection of the lymph hemangioma. Histological diagnosis on 12 November 1992, Klinisches Institut für Pathologie: "Lymph angiomatosis, not resected to healthy condition." Tumour "progressively growing".

8 April 1994 – Medical report, Universitätsklinik für Kinderheilkunde, Vienna: "Examination results after four month's Interferon therapy... Further therapy and procedure: since, based on the results of examination, neither a standstill nor a reduction of the lymph angioma by Interferon therapy could be demonstrated, this therapy has been terminated. No further therapy is currently known so that we can only offer Stefan symptomatic therapy."

21 March 1995 – Medical report,  Universitätsklinik für Kinderheilkunde, Vienna: "According to consultation with our oncologist, further tumour progression can neither be counteracted by chemotherapy nor radiotherapy. A surgical procedure is also no longer possible, so that further therapy can only be palliative." The patient was discharged to be cared for at home.

April 1995 – Beginning of therapy with Ukrain, firstly 10 mg i.v. every second day, then 5 mg i.v. twice a week. One therapy cycle lasted 2 months, pauses between therapy cycles in 1st year – 10 days, 2 weeks, 3 weeks, 1 month; in 2nd year – 4 therapy cycles with 1 month pauses between them. During this therapy the child began to speak and to walk.

In June 1997 therapy with Ukrain was interrupted. Afterwards the child's condition continually deteriorated, tumour growth progressed.

24 March 2000 – compression of the spinal cord appeared as a consequence of continued tumour growth. From the surgical report: "Indication: generalised lymph angiomatosis (intra-abdominal/thoraco-lumbal), pronounced Lipomatosis dorsi, high degree thorax deformity, state after explantation of a scrotal lymphangioma; extreme cachexia... The whole back area is arched outwards spherically because of the enormous tumour tissue...  The tumor tissue has directly infiltrated the skin, especially at the left side of the chest where it is expanded and obstructs the shoulder blade. There is also a large polycystic space requirement deep in the back musculature which also extends into the thoraco-lumbal region. (...) The tumour tissue also penetrates the wall of the thorax. Radical surgery can certainly not be discussed."

5 April 2000 – X-ray examination: "In today's x-ray ... increasingly restricted ventilation of the right lung can be observed."

6 April 2000 – Tapping of ascites with ultrasonic monitoring. "1,600 ml of a yellowish-greenish exudate could be tapped."

20 April 2000 – Tracheostomy (cut in the windpipe with the application of a canula for possible connection to a respirator).

24 May 2000 – Ultrasonic examination: "The liver is considerably enlarged... Pronounced splenomegaly (spleen enlargement)."

3 June 2000 – Patient connected to a respirator.

19 June 2000 – Ultrasonic examination: further liver enlargement up to 14 cm. Several lymph angiomas. 

23 August 2000 – "Excision of necrotic tissue" (Removal of dead tissue above the right hip).

28 August 2000 – "Epicrisis (concluding assessment) of stay as in-patient. Exsiccosis (drying out). St. febrilis (fever). Decubital ulcera (pressure sores) above the right hip and on the right shoulder blade.. Anemia (1 Ery-concentrate – blood bottle -  given). Cachexia (complete loss of strength). hyponatremia (decreased natrium level in blood). Intercostal (between the ribs) and thoracal lymph angioma with generalised lymph angiomatosis. Partial paralysis from Th5 (paralysed by a transverse lesion of the cored). Ascites (free fluid in the stomach). Home respiration therapy (respirator). Tracheostoma (canula in the windpipe). Status on discharge: weight 19.3 kg, waist 61 cm“. 

September 2000 – therapy with Ukrain restarted (continuing until now). During therapy the pain has been reduced and all pain killers were terminated. Breathing has improved and no respirator is now necessary. Severe pressure sores have healed and considerable skin defects have been completely covered without plastic-surgical intervention. Tumours in the stomach and other parts of the body have regressed during the course of Ukrain therapy.

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