Known mechanisms of the tumour-specific
cytotoxicity
of Ukrain (NSC 631570)
nDifferent
uptake in the nuclei of malignant cells compared to normal cells [12,36,73,146].
nReduction
of oxygen consumption in tumour cells but not in normal cells [4,38].
nDose-dependent
inhibition of DNA, RNA
and protein synthesis in tumour
cells [58,63].
nInhibition of cell
proliferation (cell cycle arrest) [146].
nInduction of programmed
cell death (apoptosis) [62,142,146].
nAfter Ukrain treatment
the immune system became capable of destroying
tumour cells [7,8,14,17,18,118,120].
