Results of the Ukrain (NSC 631570) Investigation at the National Cancer Institute, Bethesda, Maryland, USA

Almost all cancer cell lines demonstrated growth inhibition between 50% and 100%, which, at higher concentrations (50µg/ml) turned into a cytolytic effect with a reduction of total cell mass.

The highest concentration of Ukrain (50µg/ml) inhibited the proliferation of normal cells (endothelial cells, fibroblasts, keratinocytes, prostate epithelial cells) without any cytotoxic effect.

The chemotherapeutic compound, 5-Fluorouracil, which was investigated under identical conditions, completely inhibited growth only in a few cell lines under extremely high concentrations (500µg/ml), while a reduction in cell mass was never observed.