Known mechanisms of the tumour-specific cytotoxicity of Ukrain (NSC 631570)

• Different uptake in the nuclei of malignant cells compared to normal cells [12,36,73,146].
• Reduction of oxygen consumption in tumour cells but not in normal cells [4,38].
• Dose-dependent inhibition of DNA, RNA and protein synthesis in tumour cells [58,63].
• Inhibition of cell proliferation (cell cycle arrest) [146].
• Induction of programmed cell death (apoptosis) [62,142,146].
• After Ukrain treatment the immune system became capable of destroying tumour cells [7,8,14,17,18,118,120].